SARDH

Across TCGA patient cohorts, SARDH mutation is significantly associated with the RNA expression of many other genes, with 3,009 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SARDH-associated genes across cancer lineages are BUB3, DONSON, and CYB5R4. Each is linked with SARDH in more than 3 cancer types. Because this analysis shows association rather than direction, both SARDH-to-partner and partner-to-SARDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by SARDH-low versus SARDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARDH→partner) and Y-score (partner→SARDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.485	+2.812	<.001	<.001	3	4
UCEC	DONSON →	+0.439	+2.099	<.001	<.001	3	4
UCEC	CYB5R4 →	+0.395	+1.857	<.001	<.001	3	4
SKCM	ARNTL →	+0.447	+1.926	.004	.009	3	4
UCEC	TOMM22 →	+0.344	+1.879	.001	<.001	3	3
UCEC	POLDIP3 →	+0.365	+2.040	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,009 associations by consensus.

BUB3 by SARDH expression — UCEC

Explore this box plot interactively →