SARDH

Across TCGA pan-cancer cohorts, SARDH RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SARDH’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SARDH RNA is repressed in tumor relative to normal tissue. In most cancer types SARDH is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and LIHC are the cancer types where SARDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SARDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−2.142	<.001	8	view →
KICH	All	II,III,IV	−2.128	<.001	8	view →
LIHC	Female	All	−1.301	<.001	8	view →
CHOL	Female	All	−5.013	<.001	5	view →
HNSC	Female	IV	+0.536	.002	5	view →
UCEC	All	IV	−1.560	.008	4	view →
KIRC	Male	All	−0.852	<.001	4	view →
BRCA	All	III,IV	+0.595	.016	4	view →
LUSC	All	II,III,IV	−0.516	<.001	4	view →
LUAD	All	IV	+0.850	.041	2	view →
PAAD	Male	All	+0.440	.047	2	view →
THCA	All	All	−0.332	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SARDH–KIRP

Open the KIRP breakdown →