SARDH

Across TCGA patient cohorts, SARDH mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SARDH-associated genes across cancer lineages are PCNA, eIF4E, and Snail. Each is linked with SARDH in more than 3 cancer types. Because this analysis shows association rather than direction, both SARDH-to-partner and partner-to-SARDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SARDH-low versus SARDH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARDH→partner) and Y-score (partner→SARDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.186	+1.708	.049	.026	3	4
UCEC	eIF4E →	+0.227	+2.201	.001	<.001	3	3
UCEC	Snail →	-0.231	-3.807	.031	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.730	+3.087	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.236	-2.636	.005	<.001	3	2
UCEC	Chk2_pT68 →	-0.157	-2.312	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PCNA by SARDH expression — COAD

Explore this box plot interactively →