SARDH

Across TCGA cell cohorts, SARDH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,258 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SARDH-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, DNA replication-dependent chromatin disassembly, and Regulation of DNA-templated transcription initiation. Each is linked with SARDH in more than 7 cancer types. Because this analysis shows association rather than direction, both SARDH-to-partner and partner-to-SARDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by SARDH-low versus SARDH-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SARDH→partner) and Y-score (partner→SARDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Transcription initiation at RNA polymerase II promoter →	+0.043	+1.060	<.001	<.001	3	7
BONE	DNA replication-dependent chromatin disassembly →	+0.162	+1.036	<.001	<.001	2	8
SOFT_TISSUE	Regulation of DNA-templated transcription initiation →	+0.056	+1.268	<.001	<.001	3	7
BLOOD_Leukemia	Nuclear export →	+0.077	+1.388	<.001	<.001	2	7
BONE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.200	+1.235	.003	<.001	3	6
SOFT_TISSUE	Regulation of transcription initiation by RNA polymerase II →	+0.062	+1.476	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,258 associations by consensus.

Transcription initiation at RNA polymerase II promoter by SARDH expression — BLOOD_Leukemia

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