SARDH

Across TCGA cell cohorts, SARDH mutation is significantly associated with the RNA expression of many other genes, with 1,530 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SARDH-associated genes across cancer lineages are AGRP, PAPOLB, and SUPT20HL1. Each is linked with SARDH in more than 1 cancer types. Because this analysis shows association rather than direction, both SARDH-to-partner and partner-to-SARDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGRP grouped by SARDH-low versus SARDH-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARDH→partner) and Y-score (partner→SARDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AGRP →	+0.057	+3.825	.005	.006	3	2
OVARY	PAPOLB →	+0.011	+4.113	.001	.001	3	2
OVARY	SUPT20HL1 →	+0.061	+3.807	.001	.009	3	2
LARGE_INTESTINE	SPATA6 →	+0.454	+3.201	.007	.006	3	2
LARGE_INTESTINE	WRAP53 →	+0.519	+2.043	.002	.008	3	2
LARGE_INTESTINE	LYG1 →	+0.822	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,530 associations by consensus.

AGRP by SARDH expression — OVARY

Explore this box plot interactively →