SAR1AP4

Across TCGA pan-cancer cohorts, SAR1AP4 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated SAR1AP4 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SAR1AP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SAR1AP4 expression acts as an unfavorable survival marker, although some lineages such as LUSC and MESO show a favorable association.

CESC, STAD, and LGG are the cancer types where SAR1AP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.228	0.764	.003	72	view →
STAD	OS	Quartile	All	0.253	0.607	<.001	69	view →
LGG	DFS	Median	All	0.771	0.880	<.001	38	view →
READ	DFS	Tertile	IV	0.064	0.646	<.001	36	view →
LUSC	DFS	Tertile	II,III,IV	0.806	0.583	.011	33	view →
MESO	DFS	Tertile	All	0.886	0.366	.016	27	view →
KIRP	DFS	Tertile	IV	0.762	0.149	.049	18	view →
ACC	OS	Tertile	III,IV	0.569	0.839	.012	18	view →
LUAD	OS	Tertile	All	0.502	0.335	.025	15	view →
THCA	OS	Median	All	0.973	0.897	.017	12	view →
THYM	DFS	Tertile	II,III,IV	0.379	0.885	.010	12	view →
BLCA	OS	Tertile	All	0.443	0.703	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

SAR1AP4–CESC (OS)

Open the CESC breakdown →