SAR1A

Across TCGA pan-cancer cohorts, SAR1A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAR1A data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAR1A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SAR1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where SAR1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.955	0.570	<.001	25	view →
PDAC	DFS	Median	III,IV	0.568	0.803	.021	8	view →
UCEC	OS	Quartile	All	0.839	1.000	.015	6	view →
CCRCC	DFS	Tertile	III,IV	0.887	0.198	.024	3	view →
LSCC	OS	Quartile	III,IV	0.803	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAR1A–HNSC (DFS)

Open the HNSC breakdown →