SAR1A

Across TCGA pan-cancer cohorts, SAR1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SAR1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SAR1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAR1A is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where SAR1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAR1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.801	<.001	12	view →
LIHC	Male	III,IV	+0.716	<.001	9	view →
THCA	Male	III,IV	−0.711	<.001	8	view →
LUAD	Female	All	−0.350	<.001	7	view →
KICH	All	All	−0.608	<.001	6	view →
LUSC	All	II,III,IV	−0.447	<.001	6	view →
COAD	Male	All	+0.387	<.001	5	view →
STAD	All	II,III,IV	+0.524	.001	4	view →
CHOL	All	All	+1.070	<.001	3	view →
READ	Male	All	+0.360	.009	3	view →
KIRP	Male	All	−0.221	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SAR1A–HNSC

Open the HNSC breakdown →