SAR1A

Across TCGA patient cohorts, SAR1A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAR1A-associated genes across cancer lineages are ACC_pS79, ACC1, and Heregulin. Each is linked with SAR1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SAR1A-to-partner and partner-to-SAR1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by SAR1A-low versus SAR1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAR1A→partner) and Y-score (partner→SAR1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.389	+2.179	.025	.034	3	1
UCEC	ACC1 →	+0.360	+2.321	.048	.035	3	1
UCEC	Heregulin →	-0.195	-2.321	.001	.035	3	1
UCEC	Mre11 →	-0.095	-3.459	.027	.005	3	1
UCEC	Akt_pT308 →	+0.716	+2.999	.023	.035	3	1
UCEC	Rb →	+0.288	+2.196	.001	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ACC_pS79 by SAR1A expression — UCEC

Explore this box plot interactively →