SAP30L

Across TCGA patient cohorts, SAP30L mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAP30L-associated genes across cancer lineages are OR6C2, RNA5SP516, and RNU6-136P. Each is linked with SAP30L in more than 1 cancer types. Because this analysis shows association rather than direction, both SAP30L-to-partner and partner-to-SAP30L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C2 grouped by SAP30L-low versus SAP30L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAP30L→partner) and Y-score (partner→SAP30L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR6C2 →	+0.275	+4.690	<.001	.003	3	1
UCEC	RNA5SP516 →	+0.649	+4.937	<.001	.005	3	1
UCEC	RNU6-136P →	+0.895	+4.188	<.001	.009	3	1
UCEC	RNU6-376P →	+0.903	+5.453	<.001	.002	3	1
UCEC	TRAJ11 →	+1.013	+4.398	.001	.006	3	1
UCEC	RNU6-131P →	+0.979	+5.262	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR6C2 by SAP30L expression — UCEC

Explore this box plot interactively →