SAP30-DT

Across TCGA pan-cancer cohorts, SAP30-DT RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SAP30-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SAP30-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAP30-DT is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where SAP30-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAP30-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+2.115	<.001	12	view →
THCA	Female	II,III,IV	−0.862	<.001	11	view →
KICH	Female	All	−1.340	<.001	10	view →
BLCA	All	All	−0.827	.003	8	view →
HNSC	All	III,IV	+0.284	.003	8	view →
UCEC	All	All	−0.920	<.001	6	view →
BRCA	Female	All	−0.487	<.001	6	view →
LIHC	All	All	+0.186	<.001	6	view →
READ	All	All	−1.056	.007	4	view →
COAD	Male	II,III,IV	−0.544	.011	4	view →
LUAD	Female	III,IV	−0.532	.005	3	view →
STAD	All	All	−0.657	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SAP30-DT–KIRC

Open the KIRC breakdown →