SAP18

Across TCGA patient cohorts, SAP18 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAP18-associated genes across cancer lineages are RNU7-121P, MIR4308, and BORCS7-ASMT. Each is linked with SAP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAP18-to-partner and partner-to-SAP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-121P grouped by SAP18-low versus SAP18-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAP18→partner) and Y-score (partner→SAP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU7-121P →	+0.415	+7.731	<.001	.009	3	1
BLCA	MIR4308 →	+0.571	+5.251	<.001	.006	3	1
BLCA	BORCS7-ASMT →	+0.012	+5.588	.008	.004	3	1
BLCA	CICP15 →	+0.022	+5.497	<.001	.004	3	1
UCEC	MIR302D →	+0.865	+3.719	<.001	.008	3	1
UCEC	RNU6-1290P →	+0.580	+5.464	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

RNU7-121P by SAP18 expression — BRCA

Explore this box plot interactively →