SAP130

Across TCGA pan-cancer cohorts, SAP130 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAP130 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SAP130 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SAP130 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where SAP130 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.962	0.713	.002	23	view →
LSCC	OS	Median	All	0.922	0.721	.003	20	view →
PDAC	OS	Quartile	II,III,IV	0.350	0.671	.004	14	view →
GBM	OS	Tertile	All	0.550	0.278	.011	5	view →
OV	DFS	Median	All	0.923	0.679	.047	4	view →
HNSC	OS	Median	All	1.000	0.959	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAP130–CCRCC (OS)

Open the CCRCC breakdown →