SAP130

Across TCGA pan-cancer cohorts, SAP130 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SAP130’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SAP130 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAP130 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, KIRP, and LIHC are the cancer types where SAP130 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAP130 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.920	<.001	11	view →
KIRP	All	II,III,IV	+0.751	<.001	10	view →
LIHC	Female	II,III,IV	+1.332	<.001	9	view →
THCA	All	II,III,IV	−0.546	<.001	9	view →
LUSC	Female	All	+0.928	<.001	8	view →
BLCA	All	All	+0.658	<.001	8	view →
BRCA	All	III,IV	+0.443	<.001	8	view →
LUAD	All	All	+0.349	<.001	7	view →
KIRC	All	All	+0.270	<.001	6	view →
CHOL	Male	All	+2.006	<.001	5	view →
KICH	Female	All	−0.951	<.001	5	view →
STAD	All	II,III,IV	+0.691	.003	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SAP130–HNSC

Open the HNSC breakdown →