SAP130

Across TCGA patient cohorts, SAP130 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAP130-associated genes across cancer lineages are MEK1, Ku80, and 4E-BP1. Each is linked with SAP130 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAP130-to-partner and partner-to-SAP130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SAP130-low versus SAP130-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAP130→partner) and Y-score (partner→SAP130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.262	+1.662	.027	.010	3	2
UCEC	Ku80 →	+0.192	+1.472	.012	.007	3	2
UCEC	4E-BP1 →	+0.284	+3.029	.001	<.001	3	2
COAD	Cyclin-E1 →	+0.360	+3.178	.003	.010	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.087	.001	.004	3	1
UCEC	eIF4E →	+0.146	+2.598	.033	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by SAP130 expression — UCEC

Explore this box plot interactively →