SAP130

Across TCGA cell cohorts, SAP130 mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAP130-associated genes across cancer lineages are PRAMEF20, ODF3, and ELOA3BP. Each is linked with SAP130 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAP130-to-partner and partner-to-SAP130 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by SAP130-low versus SAP130-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAP130→partner) and Y-score (partner→SAP130) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	2
LARGE_INTESTINE	ODF3 →	+0.024	+2.736	.009	.004	3	2
LIVER	ELOA3BP →	+0.017	+4.459	<.001	.001	3	1
OESOPHAGUS	FHL5 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR2T1 →	+0.013	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CRYAA →	+0.059	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

PRAMEF20 by SAP130 expression — LUNG_SCLC

Explore this box plot interactively →