Q-omics provides the consensus-scored SAMMSON profile across patient tissues and cancer cell-line models. SAMMSON expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, SAMMSON is differentially expressed in 7, with the highest sampling consensus in LUSC. Additionally, SAMMSON RNA expression shows 12,660 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KICH, LUSC, and UVM as cancer lineages where SAMMSON shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SAMMSON — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SAMMSON survival associations across molecular data types. SAMMSON RNA expression shows survival associations in the most cancer types (21). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SAMMSON RNA expression–survival associations across cancer types. High SAMMSON expression shows unfavorable associations in KICH, UVM, KIRC and THCA, but favorable associations in UCS and LUAD. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for SAMMSON RNA expression.
This table summarizes SAMMSON tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for SAMMSON. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SAMMSON shows lower tumor expression in ESCA and BLCA and higher tumor expression in LUSC, BRCA, LUAD and LIHC. The LUSC box plot shows higher SAMMSON RNA expression in tumor versus normal tissue (log2 FC = +0.181, t-test p < 0.001).
This table shows molecular features associated with SAMMSON in patient tissues and cancer cell lines. In patient samples, SAMMSON shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
