SAMM50

Across TCGA pan-cancer cohorts, SAMM50 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAMM50 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SAMM50 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMM50 expression acts as an unfavorable survival marker, although some lineages such as OV and LSCC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where SAMM50 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.209	0.764	.001	23	view →
PDAC	DFS	Quartile	All	0.692	0.980	.001	16	view →
CCRCC	DFS	Median	III,IV	0.145	0.774	.016	7	view →
OV	DFS	Quartile	All	1.000	0.584	.049	4	view →
LSCC	OS	Tertile	All	1.000	0.955	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAMM50–LUAD (DFS)

Open the LUAD breakdown →