SAMM50

Across TCGA patient cohorts, SAMM50 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,498 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SAMM50-associated proteins across cancer lineages are ATXN10, NUP50, and XRCC6. Each is linked with SAMM50 in more than 8 cancer types. Because this analysis shows association rather than direction, both SAMM50-to-partner and partner-to-SAMM50 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAMM50 versus ATXN10 in LSCC, with a Pearson correlation of 0.61.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMM50→partner) and Y-score (partner→SAMM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ATXN10 →	+0.421	+0.501	<.001	<.001	3	9
LSCC	NUP50 →	+0.299	+0.446	<.001	<.001	3	7
OV	XRCC6 →	+0.308	+0.530	<.001	<.001	2	7
OV	TTLL12 →	+0.475	+0.577	<.001	<.001	3	6
OV	POLDIP3 →	+0.361	+0.529	<.001	.001	3	6
OV	XRCC5 →	+0.286	+0.458	<.001	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,498 associations by consensus.

SAMM50 vs ATXN10 — LSCC

Explore this scatter interactively →