SAMM50

Across TCGA patient cohorts, SAMM50 mutation is significantly associated with the RNA expression of many other genes, with 609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMM50-associated genes across cancer lineages are TRMU, DDX55, and C9orf40. Each is linked with SAMM50 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMM50-to-partner and partner-to-SAMM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by SAMM50-low versus SAMM50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMM50→partner) and Y-score (partner→SAMM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRMU →	+0.358	+3.700	.003	.001	3	2
UCEC	DDX55 →	+0.420	+2.818	.002	.001	3	2
UCEC	C9orf40 →	+0.503	+2.617	.009	.005	3	2
UCEC	CCDC43 →	+0.481	+2.732	.002	.003	3	2
UCEC	RNA5SP422 →	+0.585	+2.140	.001	.001	3	2
SKCM	XGY1 →	+0.538	+4.268	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

TRMU by SAMM50 expression — UCEC

Explore this box plot interactively →