SAMM50

Across TCGA cell cohorts, SAMM50 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SAMM50-associated genes across cancer lineages are MAGEC3, GUCA2A, and C16orf96. Each is linked with SAMM50 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMM50-to-partner and partner-to-SAMM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEC3 grouped by SAMM50-low versus SAMM50-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMM50→partner) and Y-score (partner→SAMM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAGEC3 →	+0.219	+3.855	.004	.007	3	1
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.451	+3.743	.007	.001	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MAGEC3 by SAMM50 expression — BLOOD_Leukemia

Explore this box plot interactively →