SAMD9L

Across TCGA pan-cancer cohorts, SAMD9L Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SAMD9L data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SAMD9L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SAMD9L expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

KIRP, BLCA, and UCEC are the cancer types where SAMD9L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
BLCA	DFS	Median	All	0.885	0.313	.006	26	view →
UCEC	DFS	Median	All	0.746	0.629	.011	20	view →
LUAD	OS	Median	III,IV	0.512	0.308	.001	12	view →
LIHC	DFS	Median	All	0.070	0.555	<.001	9	view →
PRAD	DFS	Median	All	0.161	0.777	<.001	4	view →
COAD	OS	Median	IV	0.140	0.657	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SAMD9L–KIRP (OS)

Open the KIRP breakdown →