SAMD9L

Across TCGA pan-cancer cohorts, SAMD9L mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SAMD9L data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SAMD9L mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD9L expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

UCEC, LUAD, and GBM are the cancer types where SAMD9L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.435	0.919	.010	32	view →
LUAD	DFS	Tertile	III,IV	1.000	0.780	.032	3	view →
GBM	DFS	Tertile	All	0.601	0.778	.032	2	view →
LSCC	OS	Tertile	II,III,IV	0.539	0.843	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SAMD9L–UCEC (DFS)

Open the UCEC breakdown →