SAMD15

Across TCGA pan-cancer cohorts, SAMD15 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SAMD15 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SAMD15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SAMD15 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UVM, ACC, and LUSC are the cancer types where SAMD15 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.037	0.858	<.001	36	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
LUSC	OS	Median	All	0.157	0.779	<.001	36	view →
UCEC	DFS	Median	III,IV	1.000	0.530	.018	18	view →
LGG	OS	Median	All	0.306	0.811	.007	6	view →
LUAD	OS	Median	III,IV	0.223	0.676	.040	3	view →
THCA	DFS	Median	All	0.196	0.830	.027	2	view →
BLCA	OS	Median	II,III,IV	0.826	0.408	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SAMD15–UVM (OS)

Open the UVM breakdown →