SAMD15

Across TCGA pan-cancer cohorts, SAMD15 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SAMD15’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SAMD15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAMD15 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, KICH, and THCA are the cancer types where SAMD15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMD15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.274	<.001	12	view →
KICH	Male	All	−1.848	<.001	11	view →
THCA	Male	All	−1.125	<.001	10	view →
BRCA	All	III,IV	+0.980	<.001	6	view →
KIRC	Male	II,III,IV	−0.510	<.001	6	view →
COAD	All	All	+0.288	<.001	6	view →
CHOL	Male	All	+1.735	<.001	5	view →
HNSC	Male	All	+0.361	.001	5	view →
READ	All	All	+0.318	.032	5	view →
LIHC	Female	All	+0.100	.009	5	view →
STAD	All	II,III,IV	+0.394	.012	3	view →
ESCA	All	All	+0.493	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SAMD15–BLCA

Open the BLCA breakdown →