SAMD15

Across TCGA patient cohorts, SAMD15 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD15-associated genes across cancer lineages are Caspase-8, Cyclin-B1, and 14-3-3_beta. Each is linked with SAMD15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD15-to-partner and partner-to-SAMD15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SAMD15-low versus SAMD15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD15→partner) and Y-score (partner→SAMD15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.219	-2.780	.017	.003	3	2
UCEC	Cyclin-B1 →	+0.497	+2.321	.016	.033	3	2
UCEC	14-3-3_beta →	-0.077	-1.834	.037	.008	3	1
UCEC	EGFR_pY1173 →	+0.068	+1.529	.020	.018	3	1
UCEC	EGFR →	-0.124	-2.973	.034	.035	3	1
UCEC	INPP4B →	-0.267	-2.459	.025	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-8 by SAMD15 expression — UCEC

Explore this box plot interactively →