SAMD15

Across TCGA cell cohorts, SAMD15 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SAMD15-associated genes across cancer lineages are MRGPRX2, FCAR, and SPANXN4. Each is linked with SAMD15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD15-to-partner and partner-to-SAMD15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRX2 grouped by SAMD15-low versus SAMD15-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD15→partner) and Y-score (partner→SAMD15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MRGPRX2 →	+0.011	+4.817	.001	.001	3	1
LUNG_SCLC	FCAR →	+0.557	+4.269	<.001	.005	3	1
LUNG_SCLC	SPANXN4 →	+0.202	+4.643	<.001	.004	3	1
LUNG_SCLC	CT47A7 →	+0.017	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MRGPRX2 by SAMD15 expression — LUNG_SCLC

Explore this box plot interactively →