Across TCGA patient cohorts, SAMD11 mutation is significantly associated with the RNA expression of many other genes, with 712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD11-associated genes across cancer lineages are GAPDHP53, MATR3P1, and MRPS16P3. Each is linked with SAMD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD11-to-partner and partner-to-SAMD11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD11→partner) and Y-score (partner→SAMD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GAPDHP53 →	+0.050	+5.912	<.001	.002	3	2
HNSC	MATR3P1 →	+0.163	+5.015	<.001	.009	3	2
HNSC	MRPS16P3 →	+0.115	+5.578	<.001	.004	3	2
HNSC	OR4F28P →	+0.482	+7.948	<.001	<.001	3	2
HNSC	TRBV17 →	+0.124	+5.241	<.001	.007	3	2
UCEC	JOSD1 →	+0.434	+3.000	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 712 associations by consensus.

Exploration

SAMD11 survival (RNA) · tumor vs normal (RNA) · all SAMD11 data types