Across TCGA pan-cancer cohorts, SAMD11 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SAMD11’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SAMD11 RNA is repressed in tumor relative to normal tissue. In most cancer types SAMD11 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
KIRC, KICH, and BRCA are the cancer types where SAMD11 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMD11 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.