Across TCGA cell cohorts, SAMD11 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAMD11-associated genes across cancer lineages are GAGE12J, TSPY10, and TBL1Y. Each is linked with SAMD11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD11-to-partner and partner-to-SAMD11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD11→partner) and Y-score (partner→SAMD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GAGE12J →	+0.063	+5.614	<.001	.002	3	1
PANCREAS	TSPY10 →	+0.053	+5.614	<.001	.002	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	KRTAP21-2 →	+0.057	+3.345	<.001	.007	3	1
LARGE_INTESTINE	OR2J1 →	+0.003	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

SAMD11 survival (RNA) · tumor vs normal (RNA) · all SAMD11 data types