SAMD10

Across TCGA patient cohorts, SAMD10 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD10-associated genes across cancer lineages are RNA5SP492, CAPZA3, and RNU6-839P. Each is linked with SAMD10 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD10-to-partner and partner-to-SAMD10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP492 grouped by SAMD10-low versus SAMD10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD10→partner) and Y-score (partner→SAMD10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP492 →	+0.432	+3.203	<.001	.003	3	2
UCEC	CAPZA3 →	+0.459	+2.650	<.001	.007	3	1
SKCM	RNU6-839P →	+0.458	+7.816	<.001	.008	3	1
SKCM	RNU6-1075P →	+0.458	+7.816	<.001	.008	3	1
SKCM	SNORA35 →	+0.404	+7.816	<.001	.008	3	1
CESC	OR2AI1P →	+0.040	+5.669	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

RNA5SP492 by SAMD10 expression — UCEC

Explore this box plot interactively →