SAMD1

Across TCGA patient cohorts, SAMD1 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD1-associated genes across cancer lineages are NEK6, NRG2, and PRCD. Each is linked with SAMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD1-to-partner and partner-to-SAMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEK6 grouped by SAMD1-low versus SAMD1-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD1→partner) and Y-score (partner→SAMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	NEK6 →	+2.674	+3.921	.001	.001	3	1
SCLC	NRG2 →	+1.134	+3.009	<.001	.003	3	1
SCLC	PRCD →	+0.306	+3.921	.006	.001	3	1
CESC	RN7SL415P →	+0.143	+5.812	<.001	.003	3	1
CESC	RPS27P12 →	+0.211	+5.969	<.001	.002	3	1
CESC	RN7SL314P →	+0.174	+6.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

NEK6 by SAMD1 expression — SCLC

Explore this box plot interactively →