SAMD1

Across TCGA pan-cancer cohorts, SAMD1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SAMD1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SAMD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAMD1 expression acts as an unfavorable survival marker, although some lineages such as STAD and GBM show a favorable association.

ACC, KIRC, and LIHC are the cancer types where SAMD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.208	0.668	<.001	126	view →
KIRC	OS	Median	All	0.558	0.701	<.001	122	view →
LIHC	OS	Median	All	0.407	0.602	<.001	94	view →
MESO	OS	Tertile	All	0.390	0.728	<.001	70	view →
KIRP	OS	Median	All	0.545	0.932	<.001	57	view →
SARC	DFS	Median	All	0.429	0.594	.001	40	view →
STAD	DFS	Median	All	0.700	0.553	.006	33	view →
GBM	DFS	Median	All	0.327	0.192	<.001	32	view →
SCLC	DFS	Quartile	II,III,IV	0.690	0.144	.003	23	view →
UVM	DFS	Median	II,III,IV	0.400	0.740	.003	19	view →
THYM	OS	Tertile	II,III,IV	0.949	0.633	.006	17	view →
HNSC	DFS	Quartile	IV	0.783	0.611	.014	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SAMD1–ACC (DFS)

Open the ACC breakdown →