SAMD1

Across TCGA patient cohorts, SAMD1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAMD1-associated genes across cancer lineages are FOXO3a_pS318_S321, S6_pS240_S244, and ARID1A. Each is linked with SAMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAMD1-to-partner and partner-to-SAMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by SAMD1-low versus SAMD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMD1→partner) and Y-score (partner→SAMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.990	.031	.036	3	1
UCEC	S6_pS240_S244 →	+0.527	+3.321	.013	.010	1	1
UCEC	ARID1A →	-0.278	-3.314	.003	.010	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FOXO3a_pS318_S321 by SAMD1 expression — UCEC

Explore this box plot interactively →