SALL3

Across TCGA pan-cancer cohorts, SALL3 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SALL3 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SALL3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SALL3 expression acts as an unfavorable survival marker.

THYM, UCS, and LUAD are the cancer types where SALL3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCS	DFS	Median	IV	0.132	0.718	.002	24	view →
LUAD	OS	Median	III,IV	0.028	0.674	<.001	24	view →
THCA	DFS	Median	All	0.038	0.841	<.001	18	view →
SCLC	DFS	Median	III,IV	0.192	0.583	.003	6	view →
ESCA	DFS	Median	III,IV	0.173	0.447	.047	3	view →
PRAD	DFS	Median	All	0.660	0.936	.012	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SALL3–THYM (OS)

Open the THYM breakdown →