SAG

Across TCGA patient cohorts, SAG protein abundance is significantly associated with the RNA expression of many other genes, with 1,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAG-associated genes across cancer lineages are MLEC, CRY2, and PDE6H. Each is linked with SAG in more than 1 cancer types. Because this analysis shows association rather than direction, both SAG-to-partner and partner-to-SAG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAG versus MLEC in OV, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAG→partner) and Y-score (partner→SAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MLEC →	+0.609	+0.613	<.001	.008	3	1
OV	CRY2 →	+0.628	+0.613	.005	.008	3	1
OV	PDE6H →	+0.386	+0.613	<.001	.008	3	1
OV	HSD17B12 →	+0.704	+0.613	<.001	.008	3	1
OV	DEDD2 →	+0.898	+0.613	.003	.008	3	1
OV	C1QL3 →	+0.618	+0.613	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,193 associations by consensus.

SAG vs MLEC — OV

Explore this scatter interactively →