SAFB

Across TCGA patient cohorts, SAFB protein abundance is significantly associated with the RNA expression of many other genes, with 18,218 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SAFB-associated genes across cancer lineages are TMEM97, ACTA2, and EMP3. Each is linked with SAFB in more than 6 cancer types. Because this analysis shows association rather than direction, both SAFB-to-partner and partner-to-SAFB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAFB versus TMEM97 in HNSC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB→partner) and Y-score (partner→SAFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM97 →	+1.068	+0.192	<.001	<.001	3	7
OV	ACTA2 →	-1.353	-0.217	.002	.004	3	6
GBM	EMP3 →	-0.670	-0.180	.001	.005	3	6
OV	COL8A1 →	-1.457	-0.222	.001	.004	3	6
OV	MIR22HG →	-0.835	-0.298	<.001	<.001	3	6
OV	SPATA20P1 →	-0.846	-0.225	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,218 associations by consensus.

SAFB vs TMEM97 — HNSC

Explore this scatter interactively →