SAFB

Across TCGA cell cohorts, SAFB RNA expression is significantly associated with the go_rna of many other GO terms, with 5,387 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SAFB-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Nucleic acid transport, and RNA transport. Each is linked with SAFB in more than 18 cancer types. Because this analysis shows association rather than direction, both SAFB-to-partner and partner-to-SAFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by SAFB-low versus SAFB-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB→partner) and Y-score (partner→SAFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Epigenetic regulation of gene expression →	+0.078	+0.733	<.001	.001	3	19
OESOPHAGUS	Nucleic acid transport →	+0.107	+0.614	<.001	<.001	3	19
OESOPHAGUS	RNA transport →	+0.107	+0.614	<.001	<.001	3	19
BONE	Positive regulation of DNA metabolic process →	+0.074	+0.832	<.001	<.001	3	19
SOFT_TISSUE	Regulation of DNA repair →	+0.077	+1.119	<.001	<.001	3	19
LUNG_SCLC	Regulation of chromatin organization →	+0.116	+0.573	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,387 associations by consensus.

Epigenetic regulation of gene expression by SAFB expression — STOMACH

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