SAFB

Across TCGA cell cohorts, SAFB mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SAFB-associated genes across cancer lineages are MCM5, SH3GL2, and XRCC6. Each is linked with SAFB in more than 1 cancer types. Because this analysis shows association rather than direction, both SAFB-to-partner and partner-to-SAFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM5 grouped by SAFB-low versus SAFB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAFB→partner) and Y-score (partner→SAFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCM5 →	+0.754	+3.064	.004	.009	3	2
LARGE_INTESTINE	SH3GL2 →	+1.325	+3.474	<.001	.003	3	2
LARGE_INTESTINE	XRCC6 →	+0.701	+3.212	<.001	.006	3	2
BLOOD_Lymphoma	GJD2 →	+0.006	+5.209	.006	.005	3	1
LARGE_INTESTINE	GCAT →	+1.224	+3.212	.003	.006	3	1
LARGE_INTESTINE	CCDC134 →	+0.726	+3.131	.005	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

MCM5 by SAFB expression — LARGE_INTESTINE

Explore this box plot interactively →