SAE1

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SAE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,694 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SAE1-associated proteins across cancer lineages are LIG1, MCM5, and SMC2. Each is linked with SAE1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SAE1-to-partner and partner-to-SAE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAE1 versus LIG1 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SAE1→partner) and Y-score (partner→SAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCLIG1 →+0.475+0.470<.001<.00139
OVMCM5 →+0.644+0.737<.001<.00139
OVSMC2 →+0.620+0.786<.001<.00138
OVSMC4 →+0.554+0.675<.001<.00138
OVMCM4 →+0.657+0.542<.001.00129
OVMCM6 →+0.640+0.708<.001<.00129
Each partner links to its Q-omics profile. Showing the 6 strongest of 16,694 associations by consensus.

SAE1 vs LIG1 — LSCC

Per-sample scatter of SAE1 vs LIG1 in LSCC (Pearson r = 0.62).

Explore this scatter interactively →

Exploration