SACS-AS1

Across TCGA pan-cancer cohorts, SACS-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SACS-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SACS-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SACS-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and ESCA show a favorable association.

KIRC, KIRP, and UVM are the cancer types where SACS-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.543	0.717	<.001	117	view →
KIRP	DFS	Median	II,III,IV	0.859	0.516	<.001	83	view →
UVM	DFS	Tertile	All	0.390	0.776	.002	66	view →
BLCA	OS	Tertile	All	0.249	0.543	<.001	64	view →
THYM	OS	Tertile	All	0.702	0.965	.002	54	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	36	view →
SKCM	DFS	Tertile	IV	0.053	0.505	.001	31	view →
ACC	DFS	Quartile	IV	0.010	0.435	.001	24	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	20	view →
DLBC	OS	Quartile	All	0.374	0.956	.006	13	view →
ESCA	DFS	Quartile	IV	0.826	0.284	.049	12	view →
PAAD	DFS	Quartile	All	0.439	0.238	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SACS-AS1–KIRC (OS)

Open the KIRC breakdown →