SACS-AS1

Across TCGA pan-cancer cohorts, SACS-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SACS-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SACS-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SACS-AS1 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

BRCA, BLCA, and STAD are the cancer types where SACS-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SACS-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.590	<.001	6	view →
BLCA	All	III,IV	−0.368	.006	6	view →
STAD	All	All	−0.168	.002	3	view →
PRAD	All	All	−0.097	.003	2	view →
KIRP	All	All	+0.093	.004	2	view →
LUSC	Female	II,III,IV	−0.071	.003	2	view →
CHOL	Male	All	+0.068	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SACS-AS1–BRCA

Open the BRCA breakdown →