SAC3D1

Across TCGA pan-cancer cohorts, SAC3D1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SAC3D1 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SAC3D1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SAC3D1 expression acts as an unfavorable survival marker, although some lineages such as STAD and DLBC show a favorable association.

LIHC, ACC, and MESO are the cancer types where SAC3D1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.584	0.789	<.001	124	view →
ACC	DFS	Quartile	All	0.249	0.798	<.001	104	view →
MESO	OS	Median	All	0.423	0.653	<.001	96	view →
KICH	OS	Median	III,IV	0.529	1.000	<.001	95	view →
KIRP	DFS	Median	All	0.851	0.964	<.001	91	view →
KIRC	OS	Tertile	All	0.538	0.725	<.001	89	view →
STAD	DFS	Tertile	All	0.614	0.486	.006	39	view →
SARC	OS	Quartile	All	0.705	0.921	.004	22	view →
PRAD	DFS	Quartile	All	0.696	0.887	<.001	18	view →
DLBC	DFS	Median	All	0.915	0.629	.012	12	view →
CHOL	DFS	Quartile	All	0.116	0.667	.019	12	view →
LUAD	OS	Quartile	All	0.727	0.877	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SAC3D1–LIHC (OS)

Open the LIHC breakdown →