SAC3D1

Across TCGA pan-cancer cohorts, SAC3D1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SAC3D1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SAC3D1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SAC3D1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where SAC3D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.889	0.599	.010	14	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.587	.008	10	view →
HNSC	DFS	Median	II,III,IV	0.988	0.899	.007	9	view →
GBM	DFS	Median	All	0.406	0.259	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SAC3D1–LSCC (OS)

Open the LSCC breakdown →