SAA2-SAA4

Across TCGA patient cohorts, SAA2-SAA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,123 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SAA2-SAA4-associated GO terms across cancer lineages are Complement activation, Humoral immune response, and Regulation of T-helper 17 type immune response. Each is linked with SAA2-SAA4 in more than 23 cancer types. Because this analysis shows association rather than direction, both SAA2-SAA4-to-partner and partner-to-SAA2-SAA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Complement activation grouped by SAA2-SAA4-low versus SAA2-SAA4-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAA2-SAA4→partner) and Y-score (partner→SAA2-SAA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Complement activation →	+0.265	+0.659	<.001	<.001	3	24
SCLC	Humoral immune response →	+0.192	+0.540	<.001	<.001	3	24
PAAD	Regulation of T-helper 17 type immune response →	+0.047	+1.359	<.001	<.001	3	22
SCLC	Complement activation, classical pathway →	+0.306	+0.673	<.001	<.001	3	22
ESCA	Antimicrobial humoral response →	+0.074	+1.007	<.001	<.001	2	23
CHOL	Acute inflammatory response →	+0.055	+3.177	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,123 associations by consensus.

Complement activation by SAA2-SAA4 expression — SCLC

Explore this box plot interactively →