SAA2-SAA4

Across TCGA pan-cancer cohorts, SAA2-SAA4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SAA2-SAA4 data layer compared with 5 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SAA2-SAA4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAA2-SAA4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUSC show a favorable association.

KIRC, LGG, and BRCA are the cancer types where SAA2-SAA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.527	0.724	<.001	122	view →
LGG	OS	Tertile	All	0.614	0.850	<.001	54	view →
BRCA	OS	Median	All	0.627	0.521	<.001	37	view →
OV	OS	Median	IV	0.492	0.735	.012	28	view →
LUSC	DFS	Quartile	III,IV	0.611	0.206	<.001	28	view →
HNSC	OS	Median	All	0.594	0.809	.001	27	view →
CHOL	OS	Median	II,III,IV	0.363	0.875	.012	25	view →
UCS	OS	Quartile	II,III,IV	0.206	0.626	.022	24	view →
ESCA	DFS	Tertile	II,III,IV	0.516	0.238	.003	22	view →
LIHC	OS	Median	III,IV	0.719	0.327	.001	18	view →
KICH	DFS	Tertile	II,III,IV	0.669	0.921	.019	16	view →
KIRP	DFS	Median	All	0.569	0.892	.002	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SAA2-SAA4–KIRC (DFS)

Open the KIRC breakdown →