SAA2-SAA4

Across TCGA patient cohorts, SAA2-SAA4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAA2-SAA4-associated genes across cancer lineages are Notch1, PAI-1, and MEK1. Each is linked with SAA2-SAA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAA2-SAA4-to-partner and partner-to-SAA2-SAA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SAA2-SAA4-low versus SAA2-SAA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAA2-SAA4→partner) and Y-score (partner→SAA2-SAA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.212	+3.013	.002	.018	3	2
UCEC	PAI-1 →	+0.413	+2.321	.016	.034	3	2
UCEC	MEK1 →	+0.407	+3.459	.026	.005	3	1
UCEC	PCNA →	+0.279	+2.321	.010	.035	3	1
UCEC	PDCD4 →	-0.803	-2.990	<.001	.036	3	1
UCEC	Annexin-1 →	+0.775	+3.019	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Notch1 by SAA2-SAA4 expression — UCEC

Explore this box plot interactively →