SAA1

Across TCGA pan-cancer cohorts, SAA1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAA1 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SAA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SAA1 expression acts as an unfavorable survival marker.

CCRCC, LUAD, and GBM are the cancer types where SAA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	II,III,IV	0.522	0.995	<.001	31	view →
LUAD	OS	Quartile	III,IV	0.237	0.984	.010	9	view →
GBM	DFS	Quartile	All	0.218	0.445	.002	8	view →
HNSC	DFS	Median	All	0.360	0.849	.045	6	view →
UCEC	DFS	Quartile	III,IV	0.428	0.886	.040	4	view →
PDAC	OS	Median	III,IV	0.599	1.000	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAA1–CCRCC (OS)

Open the CCRCC breakdown →