S1PR4

Across TCGA patient cohorts, S1PR4 mutation is significantly associated with the RNA expression of many other genes, with 3,204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible S1PR4-associated genes across cancer lineages are FANCC, NDEL1, and MINPP1. Each is linked with S1PR4 in more than 2 cancer types. Because this analysis shows association rather than direction, both S1PR4-to-partner and partner-to-S1PR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCC grouped by S1PR4-low versus S1PR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR4→partner) and Y-score (partner→S1PR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCC →	+0.502	+3.000	.001	.001	3	3
UCEC	NDEL1 →	+0.503	+3.700	<.001	.001	3	3
UCEC	MINPP1 →	+0.668	+3.470	.002	.002	3	3
SKCM	XPNPEP1 →	+0.692	+3.366	<.001	.005	3	3
UCEC	ARHGAP19 →	+0.677	+4.098	<.001	<.001	3	3
UCEC	DLAT →	+0.759	+4.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,204 associations by consensus.

FANCC by S1PR4 expression — UCEC

Explore this box plot interactively →