S1PR1

Across TCGA cell cohorts, S1PR1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible S1PR1-associated genes across cancer lineages are OR1L3, OR5V1, and MRGPRX1. Each is linked with S1PR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both S1PR1-to-partner and partner-to-S1PR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by S1PR1-low versus S1PR1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (S1PR1→partner) and Y-score (partner→S1PR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	2
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	2
LUNG_NSCLC_LUSC	MRGPRX1 →	+0.136	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	NLRP8 →	+0.023	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	ODF4 →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	FAM47B →	+0.036	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

OR1L3 by S1PR1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →